![]() ![]() The models of small molecules can be inserted into the 3D printed protein to demonstrate the protein shape-function relationship (Image 3). One way to make sure the stearic acid models are inserted correctly into the model is to hand-paint landmarks on the model at the sites of hydrophilic interaction, another way is to explore the ligand orientations along with a 3D Molecular viewer such as Mol* ( introductory video tutorial is available) available from the 1e7i Structure Summary page (Image 2). The stearic acids molecules interact with the protein in distinct orientations. In addition, the hydrophilic ‘head’ for each ligand was indicated by gluing a 5mm melty bead onto the pipe cleaner (Image 1). The stearic acid molecules were modeled using pipe cleaners. ![]() The model was hand-painted in bright green for easier visual locating of the tunnels. The tunnels can accommodate insertable small parts that will represent the small molecules. When creating the model, the ligands were removed, and hollow tunnels were modeled at the ligand interaction sites. Not very artistic but its a good way to introduce Maya to this channel. The PDB structure 1e7i has 7 molecules of stearic acid in different sites. Using Maya to make something practical with a 3D printer. The protein has multiple hydrophobic tunnels to accommodate the hydrophobic parts of the molecules it transports. It transports fatty acids and other substances in the blood. Diversity, Equity, Inclusion, and Access.Exploring the Structural Biology of Bioenergy.Exploring the Structural Biology of Cancer. ![]()
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